AMG0347

Names

[ Name ]:
AMG0347

[Synonym ]:
amg 0347
unii-cd7l9290qr

Biological Activity

[Description]:

AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm)[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Others

[References]

[1]. Chaoran Wu, et al. Effect of AMG0347, a Transient Receptor Potential Type V1 Receptor Antagonist, and Morphine on Pain Behavior after Plantar Incision。Anesthesiology. 2008 Jun;108(6):1100-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₆F₃N₃O₂

[ Molecular Weight ]:
445.47700

[ Exact Mass ]:
445.19800

[ PSA ]:
68.95000

[ LogP ]:
5.30670