N-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}sphingosine

Names

[ Name ]:
N-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}sphingosine

[Synonym ]:
nbd c6-ceramide
n-c6-nbd-d-erythro-sphingosine
n-hexanoyl-nbd-l-threo-sphingosine
n-c6-nbd-l-threo-sphingosine
c6-nbd-ceramide
n-hexanoyl-nbd-d-erythro-sphingosine
nbd hexanoic ceramide

Chemical & Physical Properties

[ Density]:
1.153 g/cm3

[ Molecular Formula ]:
C₃₀H₄₉N₅O₆

[ Molecular Weight ]:
575.74000

[ Exact Mass ]:
575.36800

[ PSA ]:
166.33000

[ LogP ]:
7.18570

[ Index of Refraction ]:
1.562

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

Articles

A small molecule inhibitor of Bcl-2, HA14-1, also inhibits ceramide glucosyltransferase.

Biochem. Biophys. Res. Commun. 433(2) , 170-4, (2013)

HA14-1 is a Bcl-2 inhibitor that is widely used for studies of apoptosis. In the course of searching for a ceramide glucosyltransferase inhibitor that catalyzes the first glycosylation step of glycosp...

A novel pathway of ceramide metabolism in Saccharomyces cerevisiae.

Biochem. J. 447(1) , 103-14, (2012)

The hydrolysis of ceramides in yeast is catalysed by the alkaline ceramidases Ypc1p and Ydc1p, two highly homologous membrane proteins localized to the ER (endoplasmic reticulum). As observed with man...

Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.

Antimicrob. Agents Chemother. 56(8) , 4296-302, (2012)

A novel and quantitative high-throughput screening approach was explored as a tool for the identification of novel compounds that inhibit chlamydial growth in mammalian cells. The assay is based on ac...