8-Azabicyclo[3.2.1]octan-3-ol,8-methyl-, benzoate (ester), hydrochloride, (3-exo)- (9CI)
Names
[ CAS No. ]:
637-23-0
[ Name ]:
8-Azabicyclo[3.2.1]octan-3-ol,8-methyl-, benzoate (ester), hydrochloride, (3-exo)- (9CI)
[Synonym ]:
Benzoesaeure-tropan-3exo-ylester,Hydrochlorid
endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester hydrochloride
pseudotropine benzoate hydrochloride
3exo-benzoyloxy-tropane,hydrochloride
8-azabicyclo(3.2.1)octan-3-ol,8-methyl-,benzoate (ester),hydrochloride,ex benzoylpseudotropine hydrochloride
Tropacaine hydrochloride
Pseudotropin
tropacocain hydrochloride
3exo-Benzoyloxy-tropan,Hydrochlorid
Tropacocaine (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) benzoate
Chemical & Physical Properties
[ Boiling Point ]:
339.9ºC at 760 mmHg
[ Molecular Formula ]:
C15H20ClNO2
[ Molecular Weight ]:
281.77800
[ Flash Point ]:
122.3ºC
[ Exact Mass ]:
281.11800
[ PSA ]:
29.54000
[ LogP ]:
3.20850
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YM4201000
- CHEMICAL NAME :
- 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, benzoate (ester), hydrochloride
- CAS REGISTRY NUMBER :
- 637-23-0
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C15-H19-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 281.81
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 7,227,1934
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 465 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RCSADO Research Communications in Substances Abuse. (PJD Pub. Ltd., P.O.Box 966, Westbury, NY 11590) V.1- 1980- Volume(issue)/page/year: 5,279,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
- REFERENCE :
- WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 120 mg/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
- REFERENCE :
- RCSADO Research Communications in Substances Abuse. (PJD Pub. Ltd., P.O.Box 966, Westbury, NY 11590) V.1- 1980- Volume(issue)/page/year: 5,279,1984
Safety Information
[ HS Code ]:
2933990090
Synthetic Route
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%