Pancreatic polypeptide

Names

[ Name ]:
Pancreatic polypeptide

Biological Activity

[Description]:

Pancreatic polypeptide is a peptide secreted by the endocrine PP cells of the pancreas that regulates pancreatic secretory activity and also affects hepatic glycogen stores and gastrointestinal secretion[1].

[Related Catalog]:

Research Areas >> Endocrinology

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[In Vitro]

Pancreatic polypeptid (PP) (0.1 μM, 48 h) 导致 mHippo E18 细胞的生长抑素分泌显着减少[1]。

[In Vivo]

Pancreatic polypeptid (PP) (1 μM, Hippocampal injection, 0.2 μL/min followed by 3 min) 可以刺激小鼠脑中含生长抑素细胞中神经元激活标记物 c-Fos 的表达，表明其可以激活小鼠海马体中含生长抑素的细胞[1]。

[References]

[1]. Wook Kim, et al. Pancreatic polypeptide inhibits somatostatin secretion. FEBS Lett. 2014 Aug 25;588(17):3233-9.

Chemical & Physical Properties

[ Density]:
1.272g/cm3

[ Boiling Point ]:
612.8ºC at 760 mmHg

[ Melting Point ]:
154-155ºC

[ Molecular Formula ]:
C₃₁H₂₄O₃

[ Molecular Weight ]:
444.52000

[ Flash Point ]:
204.3ºC

[ Exact Mass ]:
444.17300

[ PSA ]:
50.44000

[ LogP ]:
7.02750

Related Compounds

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