dipivefrin

Names

[ Name ]:
dipivefrin

[Synonym ]:
Dipivefrina
[2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate
AKPro
Dipivefrine
Dipivefrinum
Dipivefrina [INN-Spanish]
Dipivefrinum [INN-Latin]
Dipivefrin [USAN]
dipivalyl epinephrine
Propine

Biological Activity

[Description]:

Dipivefrin is a potent adrenergic agonist. Dipivefrin is an adrenergic pro-drug. Dipivefrin can be used for reduce IOP (intraocular pressure) in patients suffering from chronic open angle glaucoma[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

Human Endogenous Metabolite

[References]

[1]. Kass MA,et al. Dipivefrin and epinephrine treatment of elevated intraocular pressure: a comparative study. Arch Ophthalmol. 1979 Oct;97(10):1865-6.

[2]. Alkholief M, et al. Thermoresponsive sol-gel improves ocular bioavailability of Dipivefrin hydrochloride and potentially reduces the elevated intraocular pressure in vivo. Saudi Pharm J. 2020 Aug;28(8):1019-1029.

Chemical & Physical Properties

[ Density]:
1.097 g/cm3

[ Boiling Point ]:
473.7ºC at 760 mmHg

[ Melting Point ]:
146-147°

[ Molecular Formula ]:
C₁₉H₂₉NO₅

[ Molecular Weight ]:
351.43700

[ Flash Point ]:
240.3ºC

[ Exact Mass ]:
351.20500

[ PSA ]:
84.86000

[ LogP ]:
3.23330

[ Index of Refraction ]:
1.511

Safety Information

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%