Antiviral agent 25

Names

[ CAS No. ]:
2761367-25-1

[ Name ]:
Antiviral agent 25

Biological Activity

[Description]:

Antiviral agent 25 (compound 6g) is a new non-peptide analog covalent inhibitor of SARS-CoV-2 3CLpro. Antiviral agent 25 has a strong inhibitory effect on SARS-CoV-2 3CLpro and SARS-CoV-2 PLpro with IC50 values of 0.118 µM, 0.448 µM, respectively. Antiviral agent 25 has antiviral effect on SARS-CoV-2 with an EC50 value of 7.249 µM[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

SARS-CoV-2 3CLpro:0.118 μM (IC50)

SARS-CoV-2 PLpro:0.448 μM (IC50)


[References]

[1]. Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H12FN3S

[ Molecular Weight ]:
285.34

Related Compounds