PROTAC CYP1B1 degrader-1

Names

[ CAS No. ]:
2411389-67-6

[ Name ]:
PROTAC CYP1B1 degrader-1

Biological Activity

[Description]:

PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Signaling Pathways >> PROTAC >> PROTAC

[References]

[1]. Li Zhou, et al. Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation. Eur J Med Chem. 2020 Mar 1;189:112028.

Chemical & Physical Properties

[ Molecular Formula ]:
C43H39N5O10

[ Molecular Weight ]:
785.80

Related Compounds

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