AMPK activator 2

Names

[ CAS No. ]:
2410961-69-0

[ Name ]:
AMPK activator 2

Biological Activity

[Description]:

AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549)[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

[Target]

AMPK


[References]

[1]. Di Xiao, et al. Synthesis, biological evaluation and anti-proliferative mechanism of fluorine-containing proguanil derivatives. Bioorg Med Chem. 2020 Jan 15;28(2):115258.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H18F3N5

[ Molecular Weight ]:
301.31

Related Compounds