Methyl trans-3-(3,4,5-trimethoxyphenyl)acrylate

Names

[ CAS No. ]:
20329-96-8

[ Name ]:
Methyl trans-3-(3,4,5-trimethoxyphenyl)acrylate

[Synonym ]:
2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, methyl ester
Methyl (2E)-3-(3,4,5-trimethoxyphenyl)acrylate
methyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate
Methyl 3,4,5-trimethoxycinnamate
2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, methyl ester, (2E)-
Methyl trans-3,4,5-trimethoxycinnamate
Methyl (E)-6,7,8-trimethoxycinnamate
3,4,5-trimethoxycinnamic acid methyl ester
Methyl 3,4,5-TriMethyl cinnaMate
Cinnamic acid, 3,4,5-trimethoxy-, methyl ester
Methyl 3,4,5-trimethoxy-trans-cinnamate

Biological Activity

[Description]:

(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Olajide OA, et al. Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. Inflammopharmacology. 2020 Oct;28(5):1315-1326.

[2]. Zhao Z, et al. Potential antiarrhythmic effect of methyl 3,4,5-trimethoxycinnamate, a bioactive substance from roots of polygalae radix: suppression of triggered activities in rabbit myocytes. Biol Pharm Bull. 2013;36(2):238-44.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
370.6±37.0 °C at 760 mmHg

[ Melting Point ]:
91-92ºC

[ Molecular Formula ]:
C₁₃H₁₆O₅

[ Molecular Weight ]:
252.263

[ Flash Point ]:
163.5±26.5 °C

[ Exact Mass ]:
252.099777

[ PSA ]:
53.99000

[ LogP ]:
1.77

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.529

Safety Information

[ HS Code ]:
2918990090

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%