Tat-NR2B9c TFA

Names

[ CAS No. ]:
1834571-04-8

[ Name ]:
Tat-NR2B9c TFA

Biological Activity

[Description]:

Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Neurological Disease

[Target]

EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1] p38[2]


[References]

[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15.

[2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.

Chemical & Physical Properties

[ Molecular Formula ]:
C107H189F3N42O32

[ Molecular Weight ]:
2632.90

[ Storage condition ]:
2-8℃

Related Compounds