IDO-IN-4

Names

[ CAS No. ]:
1629125-65-0

[ Name ]:
IDO-IN-4

[Synonym ]:
Cyclopropanecarboxylic acid, 2-[4-[bis(2-methylpropyl)amino]-3-[[[(4-methylphenyl)amino]carbonyl]amino]phenyl]-, (1R,2S)-
(1R,2S)-2-[4-(Diisobutylamino)-3-{[(4-methylphenyl)carbamoyl]amino}phenyl]cyclopropanecarboxylic acid

Biological Activity

[Description]:

IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Research Areas >> Cancer

[Target]

IDO-1


[In Vitro]

IDO-IN-4 (Compound example 1 enantiomer 1) is a IDO-1 inhibitor in human IDO1/HEK293 cells[1].

[References]

[1]. Balog, et al. Preparation of cycloalkylaryl amide compounds as indoleamine 2,3-dioxygenase and therapeutic uses thereof. From PCT Int. Appl. (2014), WO 2014150677 A1 20140925.


[Related Small Molecules]

Epacadostat(INCB024360) | Indoximod | Linrodostat (BMS-986205) | NLG919 | Coptisine chloride | Navoximod | INCB024360 analogue | PF-06840003 | GNF-PF-3777 | IDO-IN-1 | IDO-IN-12 | IDO-IN-2 | IDO-IN-3 | IDO-IN-11

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
532.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H35N3O3

[ Molecular Weight ]:
437.574

[ Flash Point ]:
275.9±30.1 °C

[ Exact Mass ]:
437.267853

[ LogP ]:
5.74

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
2-8℃

Related Compounds