angiotensin iv

Names

[ Name ]:
angiotensin iv

[Synonym ]:
Ang IV Angiotensin II (3-8)
angiotensin III,1-desarginine
Ang IV,Angiotensin II (3-8)
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
Angiotensin IV trifluoroacetate salt
Angiotensin II (3-8), human

Biological Activity

[Description]:

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

Peptides

Research Areas >> Cardiovascular Disease

[Target]

Angiotensin AT1 receptor[1]

[In Vivo]

Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances[1].

[Animal admin]

Rats[1] Male Long Evans rats (350-450 g) (n=7) are given increasing bolus doses of AII (1.25, 12.5 and 125 pmol/kg) or human Angiotensin II (3-8) (0.125, 1.25 and 12.5 nmol/kg) in random order, in the morning or afternoon of the same experimental day. Injections are separated by at least 20 min to allow variables to return to baseline[1].

[References]

[1]. Gardiner SM, et al. Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br J Pharmacol. 1993 Sep;110(1):159-62.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₅₄N₈O₈

[ Molecular Weight ]:
774.90600

[ Exact Mass ]:
774.40600

[ PSA ]:
248.94000

[ LogP ]:
3.38920

MSDS

Click to get detail MSDS

Safety Information

[ WGK Germany ]:
3