Org30958

Names

[ CAS No. ]:
99957-90-1

[ Name ]:
Org30958

[Synonym ]:
Org30958

Biological Activity

[Description]:

Org30958 is a potent aromatase inhibitor in vivo.

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Others >> Aromatase

[Target]

Aromatase[1]

[In Vivo]

Besides inhibition of cornification of vaginal epithelium Org30958 (ORG 30958) decreases ovarian aromatase and plasma E2 levels in DHEAS-treated hypophysectomized rats. Plasma estradiol levels are also lowered by Org30958 in dogs which are treated with pregnant mare serum gonadotrophin in order to induce pro-estrus. Org30958 displays much less than 1/400th of the androgenic activity of testosterone propionate in immature castrated rats and appears to be devoid of estrogenic and anti-estrogenic activity in ovariectomized mature rats. A twice daily dose of 1.5 mg Org30958/kg postpones ovulation in mature female rats[1].

[References]

[1]. Geelen JA, et al. Selection of 19-(ethyldithio)-androst-4-ene-3,17-dione (ORG 30958): a potent aromatase inhibitor in vivo. J Steroid Biochem Mol Biol. 1991 Feb;38(2):181-8.

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
532.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₀O₂S₂

[ Molecular Weight ]:
378.59200

[ Flash Point ]:
220.9ºC

[ Exact Mass ]:
378.16900

[ PSA ]:
84.74000

[ LogP ]:
5.46880

[ Index of Refraction ]:
1.592

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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