Aminoguanidine hemisulfate

Names

[ CAS No. ]:
996-19-0

[ Name ]:
Aminoguanidine hemisulfate

[Synonym ]:
EINECS 213-628-7
Carbonohydrazonic diamide, sulfate (2:1)
Aminoguanidine hemisulfate
Bis(carbamimidoylhydrazinium) sulfate
MFCD00035665
Carbonohydrazonic diamide sulfate (2:1)

Biological Activity

[Description]:

Aminoguanidine hemisulfate is an inhibitor of NOS and ROS. Aminoguanidine hemisulfate abolishes ANE-induced ROS production in vitro. Aminoguanidine hemisulfate is used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

IC50: ROS, NOS[1]

[References]

[1]. Po-Li Wei, et al. Areca nut extract (ANE) inhibits the progression of hepatocellular carcinoma cells via activation of ROS production and activation of autophagy. Int J Med Sci. 2021 Aug 9;18(15):3452-3462.

[2]. You-Ting Zhu, et al. Effects of L-arginine on Nitric Oxide Synthesis and Larval Metamorphosis of Mytilus coruscus. Genes (Basel). 2023 Feb 9;14(2):450.

Chemical & Physical Properties

[ Boiling Point ]:
261.4ºC at 760mmHg

[ Melting Point ]:
200 °C

[ Molecular Formula ]:
CH₆N_4.1/₂H₂O₄

[ Molecular Weight ]:
123.13

[ Flash Point ]:
111.9ºC

[ Exact Mass ]:
246.085876

[ PSA ]:
258.82000

[ LogP ]:
0.89680

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ HS Code ]:
2925290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

PLoS ONE 10(1) , e0117842, (2015)

Mouse cytochrome P450 (CYP) 2A5 is induced by inflammatory conditions and infectious diseases that down-regulate the expression and activity of most other CYP isoforms. Enhanced oxidative stress and n...

A simple assay for mammalian spermine oxidase: a polyamine catabolic enzyme implicated in drug response and disease.

Methods Mol. Biol. 720 , 173-81, (2011)

Spermine oxidase (SMO), the most recently characterized polyamine metabolic enzyme, catalyzes the direct back-conversion of spermine to spermidine in an FAD-dependent reaction that also yields the byp...

Effects of nitric oxide on ovulation and ovarian steroidogenesis and prostaglandin production in the rabbit.

Endocrinology 138 , 3630-7, (1997)

Evidence supports the involvement of nitric oxide (NO) in ovarian physiology. The present study was undertaken to investigate the role of the NO/NO synthase (NOS) systems in ovulation, oocyte maturati...