1,3-Bis-aminooxy propane

Names

[ Name ]:
1,3-Bis-aminooxy propane

[Synonym ]:
hydroxylamine-O-[3-(aminooxy)propyl]
1,3-diaminoxypropane
1.3-Bis-aminooxy-propan
1,3-bis-aminooxy-propane
O,O'-propane-1,3-diyl-bis-hydroxylamine
Hydroxylamine,O,O'-1,3-propanediylbis

Biological Activity

[Description]:

1,3-Bis-aminooxy propane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₃H₁₀N₂O₂

[ Molecular Weight ]:
106.12400

[ Exact Mass ]:
106.07400

[ PSA ]:
70.50000

[ LogP ]:
0.55770

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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