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Benzyl-PEG2-Tos

Names

[ CAS No. ]:
98627-22-6

[ Name ]:
Benzyl-PEG2-Tos

[Synonym ]:
2-[2-(Benzyloxy)ethoxy]ethyl 4-methylbenzenesulfonate
Ethanol, 2-[2-(phenylmethoxy)ethoxy]-, 4-methylbenzenesulfonate
MFCD28064331

Biological Activity

[Description]:

Benzyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
487.4±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H22O5S

[ Molecular Weight ]:
350.429

[ Flash Point ]:
248.6±25.9 °C

[ Exact Mass ]:
350.118805

[ LogP ]:
3.00

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.549

Related Compounds