Drotrecogin alfa (activated)

Names

[ CAS No. ]:
98530-76-8

[ Name ]:
Drotrecogin alfa (activated)

Biological Activity

[Description]:

Drotrecogin alfa activated (DrotAA) is recombinant human activated protein C (APC). Drotrecogin alfa activated prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1β in rats. Drotrecogin alfa activated inhibits coagulation and inflammation and promotes fibrinolysis. Drotrecogin alfa activated can be used for severe sepsis reaearch[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vivo]

Drotrecogin alfa activated (0-20 mg/kg, IV immediately following smoke exposure, once) significantly attenuates smoke inhalation injury in a dose-dependent manner at 2 hours after insult. Drotrecogin alfa activated (20 mg/kg) has an improvement of the expiration phase of pulmonary dynamic compliance[2].

[References]

[1]. Lyseng-Williamson KA, et al. Drotrecogin alfa (activated). Drugs. 2002;62(4):617-30; discussion 631-2.

[2]. Wong SS, et al. Drotrecogin alfa (activated) prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1beta in rats. Lung. 2004;182(6):319-30.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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