isodispar B

Names

[ Name ]:
isodispar B

[Synonym ]:
5,7-dihydroxy-8-(2-methyl-1-oxobutyl)-4-phenyl-2H-[1]benzopyran-2-one
5,7-dihydroxy-8-(3-methylbutyryl)-4-phenylcoumarin
8-(3-methylbutyryl)-4-phenyl-5,7-dihydroxycoumarin
5,7-dihydroxy-8-(3-methyl-butyryl)-4-phenyl-chromen-2-one

Biological Activity

[Description]:

Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

Isodispar B (化合物 1) (0-100 μM; 72 h) 具有广谱的抗癌活性，抑制细胞增殖，IC50 为 3.84-56.73 μM[1]。 Isodispar B (1 μM 和 10 μM; 3 d) 诱导鼻咽癌细胞 (TW01、CNE1、HK1、SUNE1) 凋亡[1]。 Cell Cytotoxicity Assay[1] Cell Line: Nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1) and noncancerous nasopharyngeal cells (NP460) Concentration: 0-100 μM Incubation Time: 72 hours Result: Showed cytotoxicity and inhibited cell viability with IC50s of 3.84 μM (SUNE1), 11.49 μM (TW01), 9.74 μM (CNE1), 5.58 μM (HK1), 56.73 μM (HCC38), 52.69 μM (MDA-MB-231), 52.75 μM (MDA-ME-468), and 54.85 μM (SKBR3), respectively.

[References]

[1]. Lim C K, et al. In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species[J]. Medicinal Chemistry Research, 2016, 25(8): 1686-1694.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₈O₅

[ Molecular Weight ]:
338.35400

[ Exact Mass ]:
338.11500

[ PSA ]:
87.74000

[ LogP ]:
4.10000

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.