Streptolysin O

Names

[ Name ]:
Streptolysin O

[Synonym ]:
EINECS 308-500-3

Biological Activity

[Description]:

Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state [1][2][3][4].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

When Streptolysin O is secreted by streptococci, it is in an active state, but it rapidly oxidizes to a reversibly inactive state with the formation of disulfide bonds[2]. Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection[3].

[References]

[1]. Sierig G, et al. Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorlyencapsulated group a streptococci. Infect Immun. 2003 Jan;71(1):446-55.

[2]. Van Epps DE, et al. Streptolysin O II. Relationship of Sulfyhdryl Groups to Activity. Infect Immun. 1971 May;3(5):648-52.

[3]. Uchiyama S, et al. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015 Nov 16;6:581.

[4]. Yamamoto I, et al. Mutational and comparative analysis of streptolysin O, an oxygen-labile streptococcal hemolysin. Biosci Biotechnol Biochem. 2001 Dec;65(12):2682-9.

Chemical & Physical Properties

[ Appearance of Characters ]:
lyophilized powder

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble1mg/mL

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
UN 2811PIH 6.1 / PGI

[ WGK Germany ]:
3

Articles

Suicide cancer gene therapy using pore-forming toxin, streptolysin O.

Mol. Cancer Ther. 5 , 1610-1619, (2006)

We cloned the streptolysin O gene from the Streptococcus pyogenes genome and tested the possibility of using it as an anticancer reagent. Transient transfection of the streptolysin O gene efficiently ...

Inhibition of streptolysin O by allicin - an active component of garlic.

J. Med. Microbiol. 59 , 1044-1049, (2010)

Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated...

Neurotransmitter interactions related to central dopamine neurons.

Essays Neurochem. Neuropharmacol. 3 , 129-207, (1978)

Related Compounds

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