Picornain 3C

Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C is an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain. Picornain 3C shows endopeptidase activity by selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses[1].

Research Areas >> Infection

Research Areas >> Metabolic Disease

[1]. Sárkány Z, et al. The unusual catalytic triad of poliovirus protease 3C. Biochemistry. 2003 Jan 21;42(2):516-22.