Oxychlorpromazine
Names
[ CAS No. ]:
969-99-3
[ Name ]:
Oxychlorpromazine
[Synonym ]:
Chlorpromazine sulphoxide
Opromazine
Chlorpromazine-S-oxyd
Oxychlorpromazine
Chloropromazine sulfoxide
Opromazin
Transedon
Chlorpromazine sulfoxide
Chlorpromazine-S-oxide
Secotil
Chemical & Physical Properties
[ Density]:
1.35g/cm3
[ Boiling Point ]:
502.6ºC at 760 mmHg
[ Melting Point ]:
115°
[ Molecular Formula ]:
C17H19ClN2OS
[ Molecular Weight ]:
334.86400
[ Flash Point ]:
257.8ºC
[ Exact Mass ]:
334.09100
[ PSA ]:
42.76000
[ LogP ]:
4.84060
[ Index of Refraction ]:
1.687
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO2275000
- CHEMICAL NAME :
- Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, sulfoxide
- CAS REGISTRY NUMBER :
- 969-99-3
- BEILSTEIN REFERENCE NO. :
- 0307255
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C17-H19-Cl-N2-O-S
- MOLECULAR WEIGHT :
- 334.89
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 EG IO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 163 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,328,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 102 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 8,50,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,71S,1957
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Se Pu 30(9) , 938-42, (2012)
Based on the phenomenon that each of chlorpromazine (CPZ), promethazine (PMZ), chlorpromazine sulfoxide (CPZSO) and promethazine sulfoxide (PMZSO) could enhance the electrochemiluminescence (ECL) inte...
Free radical production by chlorpromazine sulfoxide, an ESR spin-trapping and flash photolysis study.Photochem. Photobiol. 44(1) , 5-10, (1986)
Involvement of erythrocyte skeletal proteins in the modulation of membrane fluidity by phenothiazines.
Biochemistry 26(25) , 8133-7, (1987)
The effects of phenothiazines (chlorpromazine, chlorpromazine sulfoxide, and trifluoperazine) and antimitotic drugs (colchicine and vinblastine) on the erythrocyte membrane have been investigated. Chl...