10-Ketonaltrexone

Names

[ Name ]:
10-Ketonaltrexone

[Synonym ]:
(5|A)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6,10-dione
10-Ketonaltrexone
10-oxonaltrexone
Morphinan-6,10-dione,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dih ydroxy-,(5alpha)
Naltrexone Impurity 3

Chemical & Physical Properties

[ Density]:
1.56g/cm3

[ Boiling Point ]:
633.6ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₁NO₅

[ Molecular Weight ]:
355.38400

[ Flash Point ]:
337ºC

[ Exact Mass ]:
355.14200

[ PSA ]:
87.07000

[ LogP ]:
1.10350

[ Index of Refraction ]:
1.722

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

10-Ketonaltrexone and 10-ketooxymorphone.

J. Med. Chem. 28(7) , 974-6, (1985)

Ethylketocyclazocine (1) has greater kappa/mu selectivity than cyclazocine in brain binding assays. 10-Ketonaltrexone (11) and 10-ketooxymorphone (10) were prepared from naltrexone 3-methyl ether and ...