Plocabulin

Names

[ Name ]:
Plocabulin

[Synonym ]:
plocabulin
(1Z,4S,6Z)-1-[(N-{(2Z,4Z,6E,8S)-8-[(2S)-5-Methoxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-6-methyl-2,4,6-nonatrienoyl}-3-methyl-L-valyl)amino]-1,6-octadien-4-yl carbamate
52Y8L60CR7
PM-060184
2,4,6-Nonatrienamide, N-[(1S)-1-[[[(1Z,4S,6Z)-4-[(aminocarbonyl)oxy]-1,6-octadien-1-yl]amino]carbonyl]-2,2-dimethylpropyl]-8-[(2S)-3,6-dihydro-5-methoxy-6-oxo-2H-pyran-2-yl]-6-methyl-, (2Z,4Z,6E,8S)-

Biological Activity

[Description]:

Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM; inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells; also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans.

[References]

References 1. Galmarini CM, et al. BMC Cancer. 2018 Feb 7;18(1):164. 2. Pantazopoulou A, et al. Sci Rep. 2018 Jun 5;8(1):8616. 3. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. 4. Prota AE, et al. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. View Related Products by Target Microtubule/Tubulin

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
862.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₄₅N₃O₇

[ Molecular Weight ]:
571.705

[ Flash Point ]:
475.4±34.3 °C

[ Exact Mass ]:
571.325745

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.546

Related Compounds

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