Caspase-3 Substrate

Names

[ Name ]:
Caspase-3 Substrate

[Synonym ]:
N-Acetyl-L-α-aspartyl-L-asparaginyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine
L-α-Asparagine, N-acetyl-L-α-aspartyl-L-asparaginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Biological Activity

[Description]:

Ac-DNLD-AMC is a fluorogenic caspase-3 substrate.

[In Vitro]

Ac-DNLD-AMC is a fluorogenic caspase-3 substrate.Upon enzymatic cleavage by caspase-3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-3 activity. AMC displays excitation/emission maxima of 340-360 and 440-460 nm, respectively.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1211.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₈N₆O₁₂

[ Molecular Weight ]:
674.656

[ Flash Point ]:
686.3±34.3 °C

[ Exact Mass ]:
674.254761

[ LogP ]:
1.29

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.594

Related Compounds

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