FPH2

Names

[ Name ]:
FPH2

[Synonym ]:
FPH2
4-[[[(5-Chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-1H-pyrazole-3-carboxamide
BRD-9424

Biological Activity

[Description]:

FPH2 induces of functional proliferation of primary human hepatocytes and may lead to the development of new therapeutics for liver diseases.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

Research Areas >> Metabolic Disease

[In Vitro]

FPH2 induces functional proliferation of hepatocytes in vitro, and thus may be useful for expanding mature human primary hepatocytes. FPH1 and FPH2 can increase in hepatocyte nuclei count and/or elevate the number of nuclei undergoing mitosis during primary screening, and these effects on hepatocytes are concentration dependent. Cells treated with FPH1 and FPH2 also maintain their liver-specific functions. Over 7 days, FPH2 induces hepatocyte doublings at a rate that is consistent with reported liver regeneration kinetics in vivo[1].

[References]

[1]. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9(8):514-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.45±0.1 g/cm3

[ Molecular Formula ]:
C₁₄H₁₆ClN₅O₂S

[ Molecular Weight ]:
353.82700

[ Exact Mass ]:
353.07100

[ PSA ]:
126.29000

[ LogP ]:
3.31910

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Practically insoluble (0.046 g/L) (25 ºC)

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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