Isolinderalactone

Names

[ CAS No. ]:
957-66-4

[ Name ]:
Isolinderalactone

[Synonym ]:
Isolinderalactone

Biological Activity

[Description]:

Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells[1]. Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Survivin

Signaling Pathways >> Apoptosis >> IAP

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR2

Bcl-2

[References]

[1]. Park JH, et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Cancer Lett. 2020;478:71-81.

[2]. Hwang JY, et al. Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model. Cancer Lett. 2019;443:25-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₆O₃

[ Molecular Weight ]:
244.29

[ Exact Mass ]:
244.11000

[ PSA ]:
39.44000

[ LogP ]:
3.10670

[ Storage condition ]:
-20℃

Related Compounds

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