Proflavine hydrochloride
Names
[ CAS No. ]:
952-23-8
[ Name ]:
Proflavine hydrochloride
[Synonym ]:
chlorhydrate de diamino-3,6 acridine
3,6-Acridinediamine hydrochloride
N,N,N',N'-de-tetramethyl-acridine orange
acridine-3,6-diamine hydrochloride
3,6-diaminoacridine monohydrochloride
PROFLAVINHYDROCHLORIDE
3,6-Acridinediamine, hydrochloride (1:1)
Proflavine hydrochloride
3,6-Acridinediamine, hydrochloride (8CI)
3,6-diaminoacridine-hydrochloride
EUFLAVIN
PROFLAVIN MONOHYDROCHLORIDE
3,6-Acridinediamine hydrochloride (1:1)
PROFLAVINESALTS
3,6-DiaminoacridineHCl
Proflavine monohydrochloride
EINECS 213-459-9
3,6-Diaminoacridine Hydrochloride
MFCD00066867
Chemical & Physical Properties
[ Density]:
1.346g/cm3
[ Boiling Point ]:
506.9ºC at 760mmHg
[ Melting Point ]:
270 °C
[ Molecular Formula ]:
C13H12ClN3
[ Molecular Weight ]:
245.708
[ Flash Point ]:
292.9ºC
[ Exact Mass ]:
245.071976
[ PSA ]:
64.93000
[ LogP ]:
4.51680
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AR9064000
- CHEMICAL NAME :
- Acridine, 3,6-diamino-, monohydrochloride
- CAS REGISTRY NUMBER :
- 952-23-8
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C13-H11-N3.Cl-H
- MOLECULAR WEIGHT :
- 245.73
- WISWESSER LINE NOTATION :
- T C666 BNJ EZ MZ &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 190 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - hematuria
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5040 mg/kg/6W-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27 gm/kg/109W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 gm/kg/104W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 500 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,323,1988 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Safety Information
[ Risk Phrases ]:
R40
[ RTECS ]:
AR9064000
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%