Histone H3K9me3 (1-15)

Names

[ Name ]:
Histone H3K9me3 (1-15)

Biological Activity

[Description]:

Histone H3K9me3 (1-15) (H3(1-15)K9me3) is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin. Trimethylation of histone H3 at lysine 9 is associated with gene repression, prevents transcription factor binding[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Woon EC, et al. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1631-4.

[2]. Mosch K, et al. HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats. PLoS One. 2011 Jan 18;6(1):e15894.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₆H₁₂₄N₂₅O₂₁+

[ Molecular Weight ]:
1603.85

Related Compounds

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