2-ATHBI

Names

[ Name ]:
2-ATHBI

[Synonym ]:
2-Acetyl-4-tetrahydroxybutylimidazole
1-{5-[(1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl]-1H-imidazol-2-yl}ethanone
C9H14N2O5
Ethanone, 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-
2-Athbi

Biological Activity

[Description]:

2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders. Med. Chem., 2009, 52 (13), pp 3941-3953

[2]. Schwab SR, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 9;309(5741):1735-9.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
613.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₄N₂O₅

[ Molecular Weight ]:
230.218

[ Flash Point ]:
324.8±34.3 °C

[ Exact Mass ]:
230.090271

[ PSA ]:
126.67000

[ LogP ]:
-3.67

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.635

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment.

Antimicrob. Agents Chemother. 59 , 5664-74, (2015)

There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive...

Acoustic radiation force impulse with shear wave speed quantification of pancreatic masses: A prospective study.

Pancreatology 16 , 106-9, (2016)

Acoustic Radiation Force Impulse (ARFI) is a new ultrasound technique that evaluates mechanical properties of tissues. To evaluate the use of ARFI with shear waves speed quantification for pancreatic ...

Effect of oral and parenteral administration of B6 vitamers on the lymphopenia produced by feeding ammonia caramel or 2-acetyl-4(5)-(1,2,3,4-tetrahydroxy)butylimidazole to rats.

Food Chem. Toxicol. 27(10) , 627-30, (1989)

The ability of B6 vitamers to prevent the lymphopenic effects of ammonia caramel fed to rats has been evaluated. Diets containing 10 ppm pyridoxine or pyridoxal prevented the lymphopenia produced in r...

Related Compounds

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