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isavuconazonium sulfate

Names

[ CAS No. ]:
946075-13-4

[ Name ]:
isavuconazonium sulfate

[Synonym ]:
Cresemba
Isavuconazonium sulfate
(2-{[(1-{1-[(2R,3R)-3-[4-(4-Cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1H-1,2,4-triazol-4-ium-4-yl}ethoxy)carbonyl](methyl)amino}-3-pyridinyl)methyl N-methylglycinate hydrogen sulfate

Biological Activity

[Description]:

Isavuconazonium sulfate (BAL8557-002), the prodrug of the active triazole Isavuconazole, is an orally active antifungal agent. Isavuconazonium sulfate is used for invasive aspergillosis and mucormycosis[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Schmitt-Hoffmann AH, et al. Tissue Distribution and Elimination of Isavuconazole following Single and Repeat Oral-Dose Administration of Isavuconazonium Sulfate to Rats. Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01292-17.

[2]. Murrell D, et al. Isavuconazonium sulfate: a triazole prodrug for invasive fungal infections. Int J Pharm Pract. 2017 Feb;25(1):18-30.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H36F2N8O9S2

[ Molecular Weight ]:
814.835

[ Exact Mass ]:
814.201477

[ PSA ]:
273.42000

[ LogP ]:
5.06088

[ Storage condition ]:
-20℃

Related Compounds