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20-Deoxocarnosol

Names

[ CAS No. ]:
94529-97-2

[ Name ]:
20-Deoxocarnosol

[Synonym ]:
(7β)-7,20-Epoxyabieta-8,11,13-triene-11,12-diol
2H-9,4a-(Epoxymethano)phenanthrene-5,6-diol, 1,3,4,9,10,10a-hexahydro-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-
20-Deoxocarnosol

Biological Activity

[Description]:

20-Deoxocarnosol (compound 7) is a potent anti-cancer agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Deoxocarnosol (compound 7) (0-40 µM) shows cytotoxicity with IC50 values of ˃40, 32.70, 15.15, ˃40, 24.79, ˃40 µM for :A549, SMMC-7721, HL-60, MCF-7, SW480, BEAS-2B cells, respectively[1]. Cell Viability Assay[1] Cell Line: A549, SMMC-7721, HL-60, MCF-7, SW480, BEAS-2B cells Concentration: 0-40 µM Incubation Time: Result: Showed cytotoxicity with IC50 values of ˃40, 32.70, 15.15, ˃40, 24.79, ˃40 µM for :A549, SMMC-7721, HL-60, MCF-7, SW480, BEAS-2B cells, respectively.

[References]

[1]. Guijuan Zheng, et al. Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1′-cyclohexane] motif from Salvia deserta. Org. Chem. Front., 2020,7, 3137-3145.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
463.1±45.0 °C at 760 mmHg

[ Melting Point ]:
180-183 ºC

[ Molecular Formula ]:
C20H28O3

[ Molecular Weight ]:
316.435

[ Flash Point ]:
233.9±28.7 °C

[ Exact Mass ]:
316.203857

[ PSA ]:
49.69000

[ LogP ]:
5.03

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Water Solubility ]:
Practically insoluble (0.035 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds