GAP-134 (Hydrochloride)

Names

[ CAS No. ]:
943133-81-1

[ Name ]:
GAP-134 (Hydrochloride)

[Synonym ]:
GAP134 Hydrochloride
ZP1609 Hydrochloride
CS-1101
GAP-134 (Hydrochloride)

Biological Activity

[Description]:

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Gap Junction Protein

Peptides

Research Areas >> Cardiovascular Disease

[Target]

Gap junction.

[References]

[1]. De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83.

[2]. Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8.

[3]. Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14.

[4]. Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33.

[5]. Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554

[Related Small Molecules]

Tonabersat | GAP 27 acetate salt | GAP-134 | GAP 26 trifluoroacetate salt

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₈ClN₃O₄

[ Molecular Weight ]:
327.76300

[ Exact Mass ]:
327.09900

[ PSA ]:
116.22000

[ LogP ]:
1.44420

[ Storage condition ]:
-20°C

Related Compounds

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