P11

Names

[ Name ]:
P11

[Synonym ]:
(2S,6S)-6-(4-Methylphenyl)-1-[(4-methylphenyl)sulfonyl]-2-[4-(2-methyl-2-propanyl)phenyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-, (2S,6S)-

Biological Activity

[Description]:

PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively; blocks PAFAH1b2- and PAFAH1b3-mediated hydrolysis of the substrate PAF to lyso-PAF with IC50 values of 36 nM and 880 nM; impairs tumor cell survival; in situ-active and can be used to investigate the cellular functions of PAFAH1b2/3.

[References]

References 1. Chang JW, et al. ACS Chem Biol. 2015 Apr 17;10(4):925-32. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
667.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₃NO₄S

[ Molecular Weight ]:
503.652

[ Flash Point ]:
357.2±34.3 °C

[ Exact Mass ]:
503.213043

[ LogP ]:
8.19

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds

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