AZD 1678

Names

[ Name ]:
AZD 1678

[Synonym ]:
2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide
MFCD28975034
Benzenesulfonamide, 2,3-dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)-

Biological Activity

[Description]:

AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4; shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM); inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8. Asthma Phase 1 Clinical

[References]

References 1. Kindon N, et al. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. View Related Products by Target Chemokine Receptor (CCR and CXCR) Asthma

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
469.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₈Cl₂FN₃O₃S

[ Molecular Weight ]:
352.169

[ Flash Point ]:
237.9±31.5 °C

[ Exact Mass ]:
350.964752

[ LogP ]:
3.86

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.614

Related Compounds

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