CCI-007

CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485; induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within 24h treatment; altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia.

References 1. Somers K, et al. Oncotarget. 2016 Jul 19;7(29):46067-46087. View Related Products by Target Other Targets