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Difamilast

Names

[ CAS No. ]:
937782-05-3

[ Name ]:
Difamilast

[Synonym ]:
Difamilast
N-({2-[4-(Difluoromethoxy)-3-isopropoxyphenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide
Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-

Biological Activity

[Description]:

Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM).  Dermatitis Phase 2 Clinical

[References]

References 1. Hanifin JM, et al. J Am Acad Dermatol. 2016 Aug;75(2):297-305. View Related Products by Target Phosphodiesterase (PDE) Dermatitis

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
3H24F2N2O5

[ Molecular Weight ]:
446.444

[ Exact Mass ]:
446.165314

[ LogP ]:
4.73

[ Index of Refraction ]:
1.534

Related Compounds