Difamilast
Names
[ CAS No. ]:
937782-05-3
[ Name ]:
Difamilast
[Synonym ]:
Difamilast
N-({2-[4-(Difluoromethoxy)-3-isopropoxyphenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide
Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-
Biological Activity
[Description]:
Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). Dermatitis Phase 2 Clinical
[References]
References 1. Hanifin JM, et al. J Am Acad Dermatol. 2016 Aug;75(2):297-305. View Related Products by Target Phosphodiesterase (PDE) Dermatitis
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Molecular Formula ]:
3H24F2N2O5
[ Molecular Weight ]:
446.444
[ Exact Mass ]:
446.165314
[ LogP ]:
4.73
[ Index of Refraction ]:
1.534