TPN729

TPN729 is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11; selectively inhibits PDE5 and blocks the degradation of cyclic guanosine monophosphate, and is a promising PDE5 inhibitor providing fewer side effects and better compliance.

References 1. Wang Z, et al. J Sex Med. 2013 Nov;10(11):2790-7. 2. Zhu Y, et al. J Pharm Biomed Anal. 2016 Jan 5;117:217-26. View Related Products by Target Phosphodiesterase (PDE)