MK-7288

Names

[ Name ]:
MK-7288

[Synonym ]:
Spiro[cyclohexane-1,5'(7'H)-furo[3,4-b]pyridine]-4-carboxamide, 2'-methoxy-N-methyl-7'-oxo-N-[2-(1-piperidinyl)ethyl]-
(1r,4r)-2'-Methoxy-N-methyl-7'-oxo-N-[2-(1-piperidinyl)ethyl]-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide

Biological Activity

[Description]:

A novel histamine H3 receptor inverse agonist for the treatment of sleep apnoea syndrome; significantly prolongs MWT sleep latency, and improves car driving simulation standard deviation of lane position in clinical trials. Sleep Disorder Phase 1 Clinical

[References]

References 1. Sun H, et al. J Clin Pharmacol. 2013 Dec;53(12):1294-302. View Related Products by Target Histamine Receptor Sleep Disorder

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
622.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₁N₃O₄

[ Molecular Weight ]:
401.499

[ Flash Point ]:
330.2±31.5 °C

[ Exact Mass ]:
401.231445

[ LogP ]:
1.73

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.587

Related Compounds

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