PDE5-IN-42

Names

[ Name ]:
PDE5-IN-42

Biological Activity

[Description]:

PDE5-IN-42 (Compound 42) is a potent and orally active PDE5 inhibitor with an IC50 of 0.04 nM. PDE5-IN-42 maintains selectivity over PDE6 and PDE11[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[Target]

IC50: 0.04 nM (PDE5)[1]

[References]

[1]. Tollefson MB, et al. 1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors. Bioorg Med Chem Lett. 2010 May 15;20(10):3120-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₁N₇O₃

[ Molecular Weight ]:
453.53700

[ Exact Mass ]:
453.24900

[ PSA ]:
118.29000

[ LogP ]:
3.31120

Related Compounds

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