Ropidoxuridine

Names

[ Name ]:
Ropidoxuridine

[Synonym ]:
5-Iodo-2-pyrimidinone-2'-deoxyribose
Ropidoxuridine (INN/USAN)
IPdR
Ropidoxuridine
UNII-3HX21A3SQF
Ropidoxuridine [USAN:INN]
5-Iodo-2-pyrimidinone 2' deoxyribonucleoside

Biological Activity

[Description]:

Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

[In Vitro]

Ropidoxuridine is an orally bioavailable pro-drug of IUdR (5-iodo-2'-deoxyuridine). Ropidoxuridine demonstrates strong synergy effects with Alisertib at clinically relevant concentrations[1].

[In Vivo]

In an orthotopic tumor model, Ropidoxuridine (750 mg/kg/day) and Alisertib (30 mg/kg/day) demonstrate strong synergy effects[1].

[References]

[1]. Rampurwala MM, et al. Ropidoxuridine (IPdR) potentiates alisertib (MLN8237) activity in triple-negative breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-13-16.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.22g/cm3

[ Boiling Point ]:
478.6ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₁IN₂O₄

[ Molecular Weight ]:
338.09900

[ Flash Point ]:
243.3ºC

[ Exact Mass ]:
337.97600

[ PSA ]:
84.58000

[ Index of Refraction ]:
1.759

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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