Skimmin

Names

[ CAS No. ]:
93-39-0

[ Name ]:
Skimmin

[Synonym ]:
2H-1-Benzopyran-2-one, 7- (β-D-glucopyranosyloxy)-
7-(Glucosyloxy)coumarin
Skimmin
7-Hydroxycoumarin-7-glucoside
Skimmine
UMBELLIFERONE GLUCOSIDE
2H-1-Benzopyran-2-one, 7-(β-D-glucopyranosyloxy)-
Coumarin, 7-(β-D-glucopyranosyloxy)-
2-Oxo-2H-chromen-7-yl β-D-glucopyranoside
HYDROXYCOUMARIN-GLUCOSIDE,7
Skimmin (8CI)
7-(b-D-Glucopyranosyloxy)-2H-1-benzopyran-2-one

Biological Activity

[Description]:

Skimmin (Umbelliferone glucoside) is a coumarin found in Hydrangea paniculata, inhibits immune complex deposition, with anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Zhang S, et al. Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition. Evid Based Complement Alternat Med. 2013;2013:819296.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
632.0±55.0 °C at 760 mmHg

[ Melting Point ]:
221-222ºC

[ Molecular Formula ]:
C₁₅H₁₆O₈

[ Molecular Weight ]:
324.28

[ Flash Point ]:
239.3±25.0 °C

[ Exact Mass ]:
324.084503

[ PSA ]:
129.59000

[ LogP ]:
-1.50

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.661

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition.

Evid. Based. Complement. Alternat. Med. 2013 , 819296, (2013)

Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent. In the current st...

Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats.

Eur. J. Pharmacol. 692(1-3) , 78-83, (2012)

Skimmin, a major active ingredient from Hydrangea paniculata, was considered to have the possible preventive effect on the progression of diabetic nephropathy based on the traditional Chinese medicine...

Related Compounds

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