Quinoline-2-carboxylic acid

Names

[ CAS No. ]:
93-10-7

[ Name ]:
Quinoline-2-carboxylic acid

[Synonym ]:
Quinaldic acid
2-Quinaldic acid
Quinolin-2-carboxylic acid
2-Quinolinecarboxylic acid
EINECS 202-218-3
Quinoline-2-carboxylic acid
MFCD00006752

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
348.7±17.0 °C at 760 mmHg

[ Melting Point ]:
156-158 °C(lit.)

[ Molecular Formula ]:
C₁₀H₇NO₂

[ Molecular Weight ]:
173.168

[ Flash Point ]:
164.7±20.9 °C

[ Exact Mass ]:
173.047684

[ PSA ]:
50.19000

[ LogP ]:
2.17

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.685

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UZ9100000

CHEMICAL NAME :: Quinaldic acid

CAS REGISTRY NUMBER :: 93-10-7

BEILSTEIN REFERENCE NO. :: 0126322

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H7-N-O2

MOLECULAR WEIGHT :: 173.18

WISWESSER LINE NOTATION :: T66 BNJ CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 41,708,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UZ9100000

[ HS Code ]:
29334990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis.

Org. Biomol. Chem. 13(1) , 178-84, (2014)

In the regurgitate (foregut content) of Spodoptera larvae we found high concentrations (0.5-5 mM) of 8-hydroxyquinoline-2-carboxylic acid (8-HQA). In a survey of different lepidopteran species, this c...

Hydrogen-bonded frameworks of bis(2-carboxypyridinium) hexafluorosilicate and bis(2-carboxyquinolinium) hexafluorosilicate dihydrate.

Acta Crystallogr. C 63(Pt 9) , o530-4, (2007)

In bis(2-carboxypyridinium) hexafluorosilicate, 2C(6)H(6)NO(2)+.SiF6(2-), (I), and bis(2-carboxyquinolinium) hexafluorosilicate dihydrate, 2C(10)H(8)NO(2)+.SiF6(2-).2H2O, (II), the Si atoms of the ani...

How thiostrepton was made in the laboratory.

Angew. Chem. Int. Ed. Engl. 51(50) , 12414-36, (2012)

Thiostrepton, a powerful antibiotic belonging to the thiopeptide class, was synthesized in the laboratory for the first time in 2004 through an arduous campaign involving novel strategies and tactics,...