ADAMTS-5 Inhibitor

Names

[ Name ]:
ADAMTS-5 Inhibitor

[Synonym ]:
adamts-5 inhibitor

Biological Activity

[Description]:

ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

ADAMTS-5 (aggrecanase-2) is an extracellular matrix-degrading protease implicated in cartilage destruction in arthritis[2].

[References]

[1]. Gilbert AM, et al. 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1189-92.

[2]. Wylie JD, et al. Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines. J Orthop Res. 2012 Feb;30(2):226-33.

Chemical & Physical Properties

[ Density]:
1.59±0.1 g/cm3 (20 °C, 760 mmHg)

[ Molecular Formula ]:
C₁₆H₁₁ClF₃N₃OS₃

[ Molecular Weight ]:
449.92100

[ Exact Mass ]:
448.97000

[ PSA ]:
129.61000

[ LogP ]:
5.20220

[ Storage condition ]:
-20°C

Safety Information

Related Compounds

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