TFC 007

Names

[ Name ]:
TFC 007

[Synonym ]:
5-Pyrimidinecarboxamide, N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-
N-{4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl}-2-phenoxy-5-pyrimidinecarboxamide
N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide

Biological Activity

[Description]:

TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC50 value of 83 nM). TFC-007 can be used for composing H-PGDS degradation inducer PROTAC(H-PGDS)-1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> PGE synthase

[References]

[1]. Hidetomo Yokoo, et al. Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett. 2021 Jan 14;12(2):236-241.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₇H₂₉N₅O₄

[ Molecular Weight ]:
487.55

[ Exact Mass ]:
487.221954

[ LogP ]:
1.82

[ Index of Refraction ]:
1.639

Related Compounds

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