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LAS101057

Names

[ CAS No. ]:
925676-48-8

[ Name ]:
LAS101057

[Synonym ]:
las-101057
LAS101057

Biological Activity

[Description]:

LAS101057 is a potent, selective, and orally efficacious A2B receptor antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Research Areas >> Inflammation/Immunology

[In Vivo]

At 3 mg/kg, LAS101057 is active in preventing methacholine-induced AHR, and at 10 mg/kg it inhibits AHR to methacholine to a level virtually equal to that seen with dexamethasone at 1 mg/kg[1].

[References]

[1]. Paul Eastwood, et al. Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS Med Chem Lett. 2011 Mar 10; 2(3): 213-218.


[Related Small Molecules]

CGS 21680 hydrochloride | Preladenant | ZM 241385 | CPI-444 | SCH 58261 | Vipadenant | Istradefylline | Tozadenant | AZD-4635 | Capadenoson | 2-CL-IB-MECA | PSB-12379 | CD73-IN-1 | IB-MECA | Diprophylline

Chemical & Physical Properties

[ Density]:
1.400±0.06 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
509.2±50.0 °C (760 mmHg)

[ Molecular Formula ]:
C18H14FN5O

[ Molecular Weight ]:
335.33500

[ Exact Mass ]:
335.11800

[ PSA ]:
80.66000

[ LogP ]:
3.16120

Related Compounds

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