FPND

Names

[ Name ]:
FPND

[Synonym ]:
6-{[4-(2-Fluorophenyl)-1-piperazinyl]methyl}-N-(1-naphthyl)-1,3,5-triazine-2,4-diamine
6-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-N2-1-naphthalenyl-1,3,5-triazine-2,4-diamine
FPMINT
6-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-N-(1-naphthyl)-1,3,5-triazine-2,4-diamine
1,3,5-Triazine-2,4-diamine, 6-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-N2-1-naphthalenyl-
4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-1-yl)-1,3,5-triazin-2-amine

Biological Activity

[Description]:

A novel specific ROCK1 kinase inhibitor with IC50 of 11.2 uM, without inhibitory activity against ROCK2; prevents atorvastatin-induced cerebral hemorrhage in zebrafish embryos (IC50=17.49 uM), by enhancing endothelial cell-cell junctions through inhibiting the ROCK-mediated VE-cadherin signaling pathway.

[References]

References 1. Li S, et al. Cell Death Discov. 2017 Aug 21;3:17051. View Related Products by Target ROCK

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
680.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₄FN₇

[ Molecular Weight ]:
429.493

[ Flash Point ]:
365.2±34.3 °C

[ Exact Mass ]:
429.207733

[ LogP ]:
3.57

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.717

Related Compounds

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