GPi 688

Names

[ Name ]:
GPi 688

[Synonym ]:
GPi 688

Biological Activity

[Description]:

GPi688 is a potent and orally active glycogen phosphorylase (GPa) inhibitor with IC50s of 19 nM, 61 nM and 12 nM for human liver GPa, rat liver GPa and human skeletal muscle GPa, respectively[1]. GPi688 can inhibit glucagons-mediated glucose output in rat primary hepatocytes. GPi688 can be used for researching glucagon-mediated hyperglycaemia[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

IC50: 19 nM (human liver GPa), 61 nM (rat liver GPa), 12 nM (human skeletal muscle GPa)[1]

[References]

[1]. Freeman S, et al. Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme. Br J Pharmacol. 2006;149(6):775-785.

[2]. Poucher SM, et al. An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia. Br J Pharmacol. 2007;152(8):1239-1247.

Chemical & Physical Properties

[ Density]:
1.59±0.1 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
885.9±65.0 °C (760 mmHg)

[ Molecular Formula ]:
C₁₉H₁₈ClN₃O₄S

[ Molecular Weight ]:
419.88

[ Exact Mass ]:
419.07100

[ PSA ]:
133.90000

[ LogP ]:
2.37960

GPi 688

Names

Biological Activity

Chemical & Physical Properties

Related Compounds