HA-1004
Names
[ CAS No. ]:
91742-10-8
[ Name ]:
HA-1004
Biological Activity
[Description]:
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models[1][2][3].
[Related Catalog]:
[Target]
cyclic GMP-dependent protein kinase, cyclic AMP-dependent protein[2]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C12H15N5O2S
[ Molecular Weight ]:
293.34
[ Exact Mass ]:
293.09500
[ PSA ]:
131.84000
[ LogP ]:
2.65880