Homodestcardin

Names

[ Name ]:
Homodestcardin

[Synonym ]:
(3S,6S,9S,16R,21S,21aS)-3,6-Di[(2S)-2-butanyl]-16-isobutyl-5,8,9,21-tetramethyldodecahydropyrrolo[1,2-d][1,4,7,10,13,16]oxapentaazacyclononadecine-1,4,7,10,14,17(11H,16H)-hexone
homodestcardin
Pyrrolo[1,2-d][1,4,7,10,13,16]oxapentaazacyclononadecine-1,4,7,10,14,17(11H,16H)-hexone, dodecahydro-5,8,9,21-tetramethyl-3,6-bis[(1S)-1-methylpropyl]-16-(2-methylpropyl)-, (3S,6S,9S,16R,21S,21aS)-

Biological Activity

[Description]:

Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Ai Hua Zhang, et al. Discovery of a new class of immunosuppressants from Trichothecium roseum co-inspired by cross-kingdom similarity in innate immunity and pharmacophore motif. Chem Asian J. 2013 Dec;8(12):3101-7.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
879.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₅₅N₅O₇

[ Molecular Weight ]:
621.808

[ Flash Point ]:
485.5±34.3 °C

[ Exact Mass ]:
621.410156

[ LogP ]:
0.17

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.532

Related Compounds

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