Globosuxanthone A

Names

[ Name ]:
Globosuxanthone A

[Synonym ]:
globosuxanthone A
Methyl (1R,2R)-1,2,8-trihydroxy-9-oxo-2,9-dihydro-1H-xanthene-1-carboxylate
1H-Xanthene-1-carboxylic acid, 2,9-dihydro-1,2,8-trihydroxy-9-oxo-, methyl ester, (1R,2R)-

Biological Activity

[Description]:

Globosuxanthone A is a dihydroxanthenone with obvious antifungal activity towards Fusarium graminearum, Fusarium solani, and Botrytis cinerea with MIC values of 4, 8, and 16 μg/mL, respectively. Anticancer activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Globosuxanthone A shows cytotoxicities against NCI-H460, MCF-7, SF-268, PC-3, PC-3M, LNCaP, DU-145 cells (IC50=0.65-3.6 µM)[1]. Globosuxanthone A impairs cell cycle progression of NCI-H460 and PC-3M cells leading to accumulation in the G2/M and S phases [1].

[References]

[1]. Miao C, et al. Antifungal xanthones produced by the endophytic fungus Paraconionthyrium sp. YM 311593. Folia Microbiol (Praha). 2020;65(3):567-572.

[2]. Wijeratne EM, et al. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorg Med Chem. 2006;14(23):7917-7923.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
506.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₂O₇

[ Molecular Weight ]:
304.252

[ Flash Point ]:
192.9±23.6 °C

[ Exact Mass ]:
304.058289

[ LogP ]:
2.20

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.704

Related Compounds

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